VICTOZA^®

INDICATIONS AND USAGE:

Victoza^® is an injectable prescription medicine that may improve blood sugar (glucose) in adults with type 2 diabetes when used along with diet and exercise.

Victoza^® is not recommended as the first medication to treat diabetes. Victoza^® is not insulin and has not been studied in combination with insulin. Victoza^® is not for people with type 1 diabetes or people with diabetic ketoacidosis. It is not known if Victoza^® is safe and effective in children. Victoza^® is not recommended for use in children.

IMPORTANT SAFETY INFORMATION:

In animal studies, Victoza^® caused thyroid tumors-including thyroid cancer-in some rats and mice. It is not known whether Victoza^® causes thyroid tumors or a type of thyroid cancer called medullary thyroid cancer (MTC) in people which may be fatal if not detected and treated early. Do not use Victoza^® if you or any of your family members have a history of MTC or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). While taking Victoza^®, tell your doctor if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer.

Inflammation of the pancreas (pancreatitis) may be severe and lead to death. Before taking Victoza^®, tell your doctor if you have had pancreatitis, gallstones, a history of alcoholism, or high blood triglyceride levels since these medical conditions make you more likely to get pancreatitis.

Stop taking Victoza^® and call your doctor right away if you have pain in your stomach area that is severe and will not go away, occurs with or without vomiting, or is felt going from your stomach area through to your back. These may be symptoms of pancreatitis.

Before using Victoza^®, tell your doctor about all the medicines you take, especially sulfonylurea medicines or insulin, as taking them with Victoza^® may affect how each medicine works.

Also tell your doctor if you are allergic to any of the ingredients in Victoza^®; have severe stomach problems such as slowed emptying of your stomach (gastroparesis) or problems with digesting food; have or have had kidney or liver problems; have any other medical conditions; are pregnant or plan to become pregnant. Tell your doctor if you are breastfeeding or plan to breastfeed. It is unknown if Victoza^® will harm your unborn baby or if Victoza^® passes into your breast milk.

Your risk for getting hypoglycemia, or low blood sugar, is higher if you take Victoza^® with another medicine that can cause low blood sugar, such as a sulfonylurea. The dose of your sulfonylurea medicine may need to be lowered while taking Victoza^®.

Victoza^® may cause nausea, vomiting, or diarrhea leading to dehydration, which may cause kidney failure. This can happen in people who have never had kidney problems before. Drinking plenty of fluids may reduce your chance of dehydration.

The most common side effects with Victoza^® include headache, nausea, and diarrhea. Nausea is most common when first starting Victoza^®, but decreases over time in most people. Immune system related reactions, including hives, were more common in people treated with Victoza^® compared to people treated with other diabetes drugs in medical studies.

Please click here for Victoza^® Prescribing Information and Medication Guide.

GLUCAGEN^®

INDICATIONS AND USAGE:

GlucaGen^® (glucagon [rDNA origin] for injection) is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) that can happen in people who have diabetes and use insulin. Symptoms of severe hypoglycemia include confusion, loss of consciousness, and seizures. You should only give GlucaGen^® injection if (1) the person is unconscious or (2) the person is having a seizure or (3) the person is confused and unable to eat sugar or a sugar-sweetened product. Less severe cases of hypoglycemia should be treated right away by eating sugar or a sugar sweetened product such as a regular soft drink or fruit juice. GlucaGen^® does not work if it is taken by mouth.

IMPORTANT SAFETY INFORMATION:

Do not use GlucaGen^® if you are allergic to glucagon or lactose, have a tumor of the adrenal gland called a pheochromocytoma, or have a tumor of the pancreas called insulinoma.

Hypoglycemia may happen again after receiving GlucaGen^® treatment. You must be given a fast-acting source of sugar followed by a long-acting source of sugar by mouth as soon as you are awake and able to swallow.

Tell your doctor about all medicines you take and all of your medical conditions, including if you are pregnant or breastfeeding. GlucaGen^® may affect the way other medicines work, and other medicines may affect how GlucaGen^® works.

GlucaGen^® may cause serious side effects including allergic reactions. Symptoms of a severe allergic reaction may include rash or itching, raised red patches on your skin (hives), swelling of the face, lips, tongue or throat, problems breathing or swallowing, very high or very low blood pressure, or fast or slow heart beat. The most common side effects of GlucaGen^® include nausea and vomiting.

Please click here for GlucaGen^® HypoKit Prescribing Information

LEVEMIR^®

INDICATIONS AND USAGE:

Levemir ® (insulin detemir [rDNA origin] injection) is a man-made long-acting insulin that is used to control high blood sugar in adults and children with diabetes mellitus.

IMPORTANT SAFETY INFORMATION:

Do not take Levemir® if your blood sugar is too low (hypoglycemia) or if you are allergic to anything in Levemir®. If you take too much Levemir® your blood sugar may fall too low.

Check your blood sugar levels. Ask your health care provider what your blood sugars should be and when you should check your blood sugar levels. Alcohol, including beer and wine, may affect your blood sugar when you take Levemir®.

Do not change the type of insulin you use unless told to do so by your health care provider. The amount of insulin you take as well as the best time for you to take your insulin may need to change if you take a different type of insulin.

Never mix Levemir® with other insulin products or use in an insulin pump.

Needles and Levemir® FlexPen® must not be shared.

Tell your health care provider about all medicines you take and all of your medical conditions, including if you are pregnant or breastfeeding. Your Levemir® dose may change if you take other medicines.

The most common side effect of Levemir® is low blood sugar (hypoglycemia). Other possible side effects include reactions at the injection site (like redness, swelling and itching), and allergic reactions. Get medical help right away if you experience signs of serious allergic reaction such as body rash, trouble with your breathing, fast heartbeat, or sweating. Ask your doctor or pharmacist for further information.

Please click here for Levemir® Prescribing Information

NOVOLOG^®

INDICATIONS AND USAGE:

NovoLog ® (insulin aspart [rDNA origin] injection) is a man-made insulin that is used to control high blood sugar in adults and children with diabetes mellitus.

IMPORTANT SAFETY INFORMATION:

Do not take NovoLog® if your blood sugar is too low (hypoglycemia) or if you are allergic to anything in NovoLog®. If you take too much NovoLog® your blood sugar may fall too low.

NovoLog® is a fast-acting insulin. You should eat a meal within 5 to 10 minutes after using NovoLog® to avoid low blood sugar. Do not inject NovoLog® if you do not plan to eat right after using NovoLog®. Check your blood sugar levels. Ask your health care provider what your blood sugars should be and when you should check your blood sugar levels. Alcohol, including beer and wine, may affect your blood sugar when you take NovoLog®.

Do not change the type of insulin you use unless told to do so by your health care provider. The amount of insulin you take as well as the best time for you to take your insulin may need to change if you take a different type of insulin.

Do not mix NovoLog® with any other insulins when used in a pump or with any insulins other than NPH when used with injections by syringe.

Needles and NovoLog® FlexPen® must not be shared.

Tell your health care provider about all medicines you take and all of your medical conditions, including if you are pregnant or breastfeeding. Your NovoLog® dose may change if you take other medicines.

NovoLog® has not been studied in children with type 2 diabetes or in children with type 1 diabetes under the age of two.

The most common side effect of NovoLog® is low blood sugar (hypoglycemia). Other possible side effects include reactions at the injection site (like redness, swelling and itching), and allergic reactions. Get medical help right away if you experience signs of serious allergic reaction such as body rash, trouble with your breathing, fast heartbeat, or sweating. Ask your doctor or pharmacist for further information.

Please click here for NovoLog® Prescribing Information

NOVOLOG^® MIX 70/30

INDICATIONS AND USAGE:

NovoLog® Mix 70/30 (70% insulin aspart protamine suspension and 30% insulin aspart injection, [rDNA origin]) is a man-made insulin that is used to control high blood sugar in adults with diabetes mellitus.

It is not known if NovoLog® Mix 70/30 is safe or effective in children.

IMPORTANT SAFETY INFORMATION:

Do not take NovoLog® Mix 70/30 if your blood sugar is too low (hypoglycemia) or if you are allergic to any of the ingredients in NovoLog® Mix 70/30. If you take too much NovoLog® Mix 70/30, your blood sugar may fall too low (hypoglycemia).

NovoLog® Mix 70/30 starts acting fast. If you have Type 1 diabetes, inject it up to 15 minutes before you eat a meal. If you have Type 2 diabetes, you may inject NovoLog® Mix 70/30 up to 15 minutes before or after starting your meal.

Check your blood sugar levels regularly. Ask your healthcare provider what your blood sugars should be and when you should check your blood sugar levels. Do not make any changes to your dose or type of insulin unless your healthcare provider tells you to. Alcohol, including beer and wine, may affect your blood sugar when you take NovoLog® Mix 70/30.

Before using NovoLog® Mix 70/30, tell your health care provider about all medicines you take and all of your medical conditions, including if you have kidney or liver problems or if you are pregnant or breastfeeding. It is not known if NovoLog® Mix 70/30 will harm your unborn baby or pass into breast milk. Your NovoLog® Mix 70/30 dose may change if you take other medicines.

Do not inject NovoLog® Mix 70/30 with any other insulin products or use in an insulin pump.

Do not share needles, insulin pens or syringes with others.

The most common side effects of NovoLog® Mix 70/30 include skin thickening or pits at the injection site (lipodystrophy), weight gain, swelling of your hands and feet, and vision changes. Serious adverse events may include low blood sugar (hypoglycemia), low potassium in your blood (hypokalemia), local allergic reactions at the injection site (like redness, swelling, and itching), and whole body reactions. Get medical help right away if you have any of these symptoms of an allergic reactions: a rash over the whole body, have trouble breathing, fast heart rate, sweating or if you feel faint. Ask your health care provider or pharmacist for more information.

Please click here for NovoLog^® Mix 70/30 Prescribing Information

PRANDIN^®

INDICATIONS AND USAGE:

Prandin^® (repaglinide) tablets are used in addition to diet and exercise to control blood sugar levels in adults with type 2 diabetes.

IMPORTANT SAFETY INFORMATION:

Do not take Prandin^® if you have diabetic ketoacidosis (a complication of diabetes resulting in a buildup of ketones [a by-product of fat breakdown] in the body) with or without coma, type 1 diabetes or are allergic to Prandin^® or any of its ingredients. Prandin^® should not be used if you are also taking NPH insulin. Do not take Prandin® if you take a prescription medication called gemfibrozil. Hypoglycemia (low blood sugar) is possible in people taking Prandin^®. Mild to moderate cases of hypoglycemia occurred in 16% of patients taking Prandin^® alone.

In one-year clinical studies in patients taking only Prandin^®, the most common side effects leading to discontinuation of Prandin^® were hyperglycemia (high blood sugar), hypoglycemia, and related symptoms. The most common other side effects reported form other studies comparing Prandin® to placebo or other diabetes medicines were cold- and flu-like symptoms, headache, sinusitis, nausea, diarrhea, joint ache, and back pain. In trials comparing Prandin^® to another class of diabetes medications called sulfonylureas, serious heart-related side effects, including ischemia (decreased blood blow to the heart), were higher with Prandin^® (4% compared to 3%). In 1 year long controlled studies, treatment with Prandin^® was not associated with an increased risk of death when compared to other diabetes medicines taken by mouth.

In clinical studies comparing Prandin^® to another class of diabetes medications called thiazolidinediones (TZD), hypoglycemia occurred in 7% of patients taking both drugs, 7% of patients taking Prandin^® alone, and 2% of patients taking only TZD. The percentage of patient having fluid retention in the extremities per 24 weeks of treatment was 5% for patients taking both Prandin^® and a TZD and 4% for patients taking only a TZD. No fluid retention in the extremities was reported in patients taking Prandin^® alone. Two patients, both with a history of heart blood vessel disease, reported fluid retention with heart failure; no cases with patients taking either drug alone were reported. The average change in weight in patients taking Prandin^® and a TZD was +4.9 kilograms.

Please click here for Prandin® Prescribing Information