Scientist II - New Modality Chemist

Job description

Job description


Indianapolis, United States

Job category


About the Department                                                                                                                                     

The Novo Nordisk Research Center Indianapolis, Inc. (NNRCII) supports our global mission to transform the treatment of chronic diseases through the discovery of high-quality drug candidates and disruptive technology innovations. We operate as a Transformational Research Unit (TRU), meaning we are a relatively small team of elite interdisciplinary researchers working in unison yet with autonomy relative to the global R&D organization—essentially a biotech-like ecosystem within the Novo Nordisk biosphere. We have multiple strategic collaborations with internationally acclaimed academic centers of excellence and emerging biotech’s, which we view as an integral part of our discovery research process and essential for our fundamental scientific endeavors. Collectively, this allows us to focus our efforts on data generation and translation of research hypotheses to foster quick data-driven, non-stochastic decisions. 

We are keenly focused on grassroot discovery projects pertaining to cardio-metabolic diseases and rare endocrine disorders, and we are responsible for driving projects from ideation to clinical development. In addition to drug discovery research, we also explore novel chemical biology technologies to optimize the therapeutic applications of peptides/proteins as well as biotechnologies that catalyze the pursuits of therapeutic modalities new to Novo Nordisk.   Are you ready to make a difference?


The Position

The Scientist II will provide scientific leadership in the identification and validation of new drug targets, advancing novel therapies to the clinic, and developing technologies to accelerate drug research. This will be achieved by coordinating multiple research activities involving cross-functional project teams to ensure achievement of key deliverables. The Scientist II will represent the organization to the external scientific community through publication and presentation of research and through participation in external collaborations.



Reports to of the Site Head of Novo Nordisk Research Center Indianapolis & Senior Director of the Transformational Research Unit-Chemical Biology. 
Internal relationships include project teams and research colleagues in Seattle, Indianapolis, Denmark, and around the globe. Communicates data externally when required. May oversee parts of discovery research chemistry operations and laboratory facilities. May manage external collaborations with academic and industry partners. Individual Contributor: does not manage other employees or contingent workers.


Essential Functions

  • Advances research projects by demonstrating technical expertise, creativity, and scientific leadership in discovery research chemistry, particularly with specialization in targeted protein degradation and/or bio-conjugated oligonucleotides, and a broad knowledge of related disciplines.
  • Spearhead local drug discovery efforts aimed at exploring new chemical modalities and methodologies. This includes developing, enacting, and performing strategies for proof of concept and identifying subsequent fit-for-purpose applications
  • Analyzes complex data with high degree of sophistication, connecting disparate datasets to reach conclusions and set direction on experiments. Contributes strong scientific acumen to enable projects and advance the research agenda.
  • Effectively communicates and collaborates across global sites and guides project strategy by providing leadership of cross-functional project teams. Represents the organization through external communication of impactful scientific research in the form of presentation at external conferences and publication in scientific journals and patents. May manage external collaborations.
  • Maintains a strong understanding of theoretical knowledge and a connection to the external scientific community through continuous evaluation of relevant literature. Expands the capabilities of discovery research chemistry through the generation of new ideas, evaluation of new chemistry methodology, and implementation of technologies that add value.
  • Leads cross-functional experimental teams to achieve project goals, mentor junior staff, and provide training.
  • Influences the research pipeline by proposing new projects that support the strategic agenda.


Physical Requirements:
Novo Nordisk requires all employees, both Field and Office-based, to be fully vaccinated with a COVID-19 vaccine prior to the first date of employment. As required by applicable law, Novo Nordisk will consider requests for reasonable accommodation for those unable to be vaccinated. You will be required to upload an image of your COVID-19 vaccine card at the time of hire and/or on your first day of employment




  • Bachelor 's degree with 15+ years’ relevant experience required. Degree in chemistry or biochemistry preferred.
    • OR a Doctoral degree with 4+ years’ post-doctoral and/or industry relevant experience, or a Master’s degree  with 10+ years’ relevant experience, can be considered.
  • Relevant required experience includes: 
    • Medicinal chemistry experience with targeted protein degradation technologies (LyTAC, ProTAC, etc.) including in silico design and optimization principles and hit-to-lead generations and validation.
    • Medicinal chemistry experience with multi-functional oligonucleotide conjugates specifically designed for selective biodistribution or extra-hepatic tissue targeting 
    • Synthetic skills including organic synthesis, oligonucleotide synthesis, and biomolecular conjugation.
    • Experience in design and biochemical characterization of oligonucleotides, targeting chimeras and their bioconjugation chemistries
    • Structure-function based drug design knowledge and application for the optimization of drug candidates
    • Strong working knowledge of modern synthetic chemistry methodologies.    
  • Strong interpersonal skills to be effective in multiple high-functioning teams.
  • Strong written and oral communication skills.


  • Preferred experience includes:
    • Strong publication and patent track record


We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. 


At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.


Novo Nordisk is an equal opportunity employer.  Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.


If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-855-411-5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.